{"id":1312,"date":"2026-02-03T16:49:01","date_gmt":"2026-02-03T16:49:01","guid":{"rendered":"https:\/\/wickedsister.evit.com.au\/index.php\/2026\/02\/03\/b-cell-follicles-as-a-central-problem-for-the-cause-of-brain-damage\/"},"modified":"2026-02-03T16:49:01","modified_gmt":"2026-02-03T16:49:01","slug":"b-cell-follicles-as-a-central-problem-for-the-cause-of-brain-damage","status":"publish","type":"post","link":"https:\/\/wickedsister.evit.com.au\/index.php\/2026\/02\/03\/b-cell-follicles-as-a-central-problem-for-the-cause-of-brain-damage\/","title":{"rendered":"B cell follicles as a central problem for the cause of  Brain Damage"},"content":{"rendered":"<div class=\"twitter-share\"><a href=\"https:\/\/twitter.com\/intent\/tweet?url=https%3A%2F%2Fmultiple-sclerosis-research.org%2F2026%2F02%2Fb-cell-follicles-as-a-central-problem-for-the-cause-of-brain-damage%2F&#038;via=the_MSBlog\" class=\"twitter-share-button\" data-size=\"large\">Tweet<\/a><\/div>\n<p>Lymphotoxin-dependent elevated meningeal 1 CXCL13:BAFF ratios drive grey matter injury,\u00a0<em>Nature Immunology<\/em>\u00a0(2026).\u00a0<a href=\"https:\/\/dx.doi.org\/10.1038\/s41590-025-02359-5\" target=\"_blank\" rel=\"noreferrer noopener\">DOI: 10.1038\/s41590-025-02359-5<\/a><\/p>\n<p>CXCL13 (C-X-C motif chemokine ligand 13) is a chemokine (<em>a molecule that cells migrate towards<\/em>) that acts as a B-cell attractant, guiding their movement and organizing immune responses, especially in lymphoid tissues. It binds to the CXCR5 receptor\u00a0(high on B cells and T cells that help B cells), playing key roles in antibody responses, and the development of memory B cells. Beyond normal immunity, elevated CXCL13 levels are linked to various autoimmune diseases (like rheumatoid arthritis, lupus, multiple sclerosis) and cancers.\u00a0<\/p>\n<p>BAFF refers to B cell activating factor, a crucial cytokine in the immune system for B-cell survival, maturation, and differentiation, vital for the immune response.<\/p>\n<p>Its overactivity is linked to autoimmune diseases like lupus, rheumatoid arthritis, and multiple sclerosis<\/p>\n<p>To test the validity of their findings in humans, the researchers measured the CXCL13-to-BAFF ratio in postmortem brain tissues from people who had MS and in the cerebrospinal fluid of a living cohort of people with MS. In both cases, a high CXCL13-to-BAFF ratio was associated with greater compartmentalized inflammation in the brain.<\/p>\n<p><em>Source: <a href=\"https:\/\/multiple-sclerosis-research.org\/2026\/02\/b-cell-follicles-as-a-central-problem-for-the-cause-of-brain-damage\/?utm_source=rss&#038;utm_medium=rss&#038;utm_campaign=b-cell-follicles-as-a-central-problem-for-the-cause-of-brain-damage\" rel=\"nofollow noopener\" target=\"_blank\">multiple-sclerosis-research.org<\/a><\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tweet Lymphotoxin-dependent elevated meningeal 1 CXCL13:BAFF ratios drive grey matter injury,\u00a0Nature Immunology\u00a0(2026).\u00a0DOI: 10.1038\/s41590-025-02359-5 CXCL13 (C-X-C motif chemokine ligand 13) is a chemokine (a molecule that cells migrate towards) that acts as a B-cell attractant, guiding their movement and organizing immune responses, especially in lymphoid tissues. It binds to the CXCR5 receptor\u00a0(high on B cells and&#8230;<\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[11,15,9,8,13,14,12,10],"class_list":["post-1312","post","type-post","status-publish","format-standard","hentry","category-multiple-sclerosis-research","tag-brain-repair","tag-marburg-type-ms","tag-ms","tag-multiple-sclerosis","tag-myelin","tag-neuroregeneration","tag-oligodendrocyte","tag-remyelination"],"_links":{"self":[{"href":"https:\/\/wickedsister.evit.com.au\/index.php\/wp-json\/wp\/v2\/posts\/1312","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wickedsister.evit.com.au\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wickedsister.evit.com.au\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/wickedsister.evit.com.au\/index.php\/wp-json\/wp\/v2\/comments?post=1312"}],"version-history":[{"count":0,"href":"https:\/\/wickedsister.evit.com.au\/index.php\/wp-json\/wp\/v2\/posts\/1312\/revisions"}],"wp:attachment":[{"href":"https:\/\/wickedsister.evit.com.au\/index.php\/wp-json\/wp\/v2\/media?parent=1312"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wickedsister.evit.com.au\/index.php\/wp-json\/wp\/v2\/categories?post=1312"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wickedsister.evit.com.au\/index.php\/wp-json\/wp\/v2\/tags?post=1312"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}