{"id":1470,"date":"2026-02-27T11:01:00","date_gmt":"2026-02-27T11:01:00","guid":{"rendered":"https:\/\/wickedsister.evit.com.au\/index.php\/2026\/02\/27\/controling-ebv-infection\/"},"modified":"2026-02-27T11:01:00","modified_gmt":"2026-02-27T11:01:00","slug":"controling-ebv-infection","status":"publish","type":"post","link":"https:\/\/wickedsister.evit.com.au\/index.php\/2026\/02\/27\/controling-ebv-infection\/","title":{"rendered":"Controling EBV infection"},"content":{"rendered":"<div class=\"twitter-share\"><a href=\"https:\/\/twitter.com\/intent\/tweet?url=https%3A%2F%2Fmultiple-sclerosis-research.org%2F2026%2F02%2Fcontroling-ebv-infection%2F&#038;via=the_MSBlog\" class=\"twitter-share-button\" data-size=\"large\">Tweet<\/a><\/div>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41714741\/\">Host control of persistent Epstein-Barr virus infection.<\/a><\/p>\n<p>Schmidt A, Alawathurage TM, David FS, Ogawa Y, Frach L, Richter S, Schaefer M, Mathey CM, Henne SK; Japan COVID-19 Task Force; Forstner AJ, Dilthey AT, Pr\u00f6bstel AK, Boztug K, N\u00f6then MM, Namkoong H, Okada Y, Beins EC, Ludwig KU. Nature. 2026. doi: 10.1038\/s41586-026-10274-4. Online ahead of print.<\/p>\n<p>Epstein-Barr virus (EBV) infects \u224890-95% of the global population and persists in B cells as a life-long infection. Prior EBV-infection is associated with autoimmune and neoplastic (<em>cancer<\/em>) disease. Still, the biological basis of host control during EBV persistence remains unclear. Here, we report the identification of non-genetic and genetic factors that are associated with EBVcontrol during persistent infection. Using blood-based genome sequence (GS) data from 486,315 UK Biobank and 336,123 All of Us participants, <strong>we identified short read-pairs mapping to the EBV genome in 16.2% and 21.8% of individuals<\/strong>, respectively. EBV-read detection (EBVread+) reflects increased viral load in blood cells, as shown by orthogonal measurements, and was associated with HIV infection, immunosuppressive drug intake, and current smoking.<strong> Genome-wide analyses of EBVread+ identified strong associations at the Major Histocompatibility Complex (MHC), including 54 independent HLA-alleles of MHC class I and II, and at 27 genomic regions outside MHC.<\/strong>&#8230;Analysis of individuals with EBV-associated diseases\u00a0revealed a higher polygenic burden of EBVread+ for HLA-alleles at MHC class I in multiple sclerosis (driven by HLA-A*02:01), and at MHC class II in rheumatoid arthritis.  (<em>HLA-A*0201 is associated with MS resistance and lack of EBV viral load in other studies<\/em>, <em>Why no associated with HLA-DR B1:1501<\/em>?). <strong>Phenome-wide analyses identified a polygenic overlap of EBVread+ with inflammatory bowel disease, hypothyroidism, and type 1 diabetes<\/strong>. Our study establishes by-products of human GS as a surrogate marker of EBV viral load. This will facilitate investigation and treatment for EBV and other persistent viral infections.<\/p>\n<p><em>Source: <a href=\"https:\/\/multiple-sclerosis-research.org\/2026\/02\/controling-ebv-infection\/?utm_source=rss&#038;utm_medium=rss&#038;utm_campaign=controling-ebv-infection\" rel=\"nofollow noopener\" target=\"_blank\">multiple-sclerosis-research.org<\/a><\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tweet Host control of persistent Epstein-Barr virus infection. Schmidt A, Alawathurage TM, David FS, Ogawa Y, Frach L, Richter S, Schaefer M, Mathey CM, Henne SK; Japan COVID-19 Task Force; Forstner AJ, Dilthey AT, Pr\u00f6bstel AK, Boztug K, N\u00f6then MM, Namkoong H, Okada Y, Beins EC, Ludwig KU. Nature. 2026. doi: 10.1038\/s41586-026-10274-4. Online ahead of&#8230;<\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[11,15,9,8,13,14,12,10],"class_list":["post-1470","post","type-post","status-publish","format-standard","hentry","category-multiple-sclerosis-research","tag-brain-repair","tag-marburg-type-ms","tag-ms","tag-multiple-sclerosis","tag-myelin","tag-neuroregeneration","tag-oligodendrocyte","tag-remyelination"],"_links":{"self":[{"href":"https:\/\/wickedsister.evit.com.au\/index.php\/wp-json\/wp\/v2\/posts\/1470","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wickedsister.evit.com.au\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wickedsister.evit.com.au\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/wickedsister.evit.com.au\/index.php\/wp-json\/wp\/v2\/comments?post=1470"}],"version-history":[{"count":0,"href":"https:\/\/wickedsister.evit.com.au\/index.php\/wp-json\/wp\/v2\/posts\/1470\/revisions"}],"wp:attachment":[{"href":"https:\/\/wickedsister.evit.com.au\/index.php\/wp-json\/wp\/v2\/media?parent=1470"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wickedsister.evit.com.au\/index.php\/wp-json\/wp\/v2\/categories?post=1470"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wickedsister.evit.com.au\/index.php\/wp-json\/wp\/v2\/tags?post=1470"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}