{"id":620,"date":"2025-10-10T23:46:44","date_gmt":"2025-10-10T23:46:44","guid":{"rendered":"https:\/\/wickedsister.evit.com.au\/index.php\/2025\/10\/10\/future-treatment-may-get-easier\/"},"modified":"2025-10-10T23:46:44","modified_gmt":"2025-10-10T23:46:44","slug":"future-treatment-may-get-easier","status":"publish","type":"post","link":"https:\/\/wickedsister.evit.com.au\/index.php\/2025\/10\/10\/future-treatment-may-get-easier\/","title":{"rendered":"Future treatment may get easier"},"content":{"rendered":"<div class=\"twitter-share\"><a href=\"https:\/\/twitter.com\/intent\/tweet?url=https%3A%2F%2Fmultiple-sclerosis-research.org%2F2025%2F10%2F54216%2F&#038;via=the_MSBlog\" class=\"twitter-share-button\" data-size=\"large\">Tweet<\/a><\/div>\n<p>I am often accused of being a glass half empty Yorkshireman and never sufficiently positive. But I think MS can learn from Lupus and it&#8217;s little cousin called neuromyelitis optica or historically Devics multiple sclerosis. CAR-T therapy where you make T cells target something else using a chimeric antigen receptor. Chimeric because the antigen receptor is part T cells and delivers the T cells activation signal and part B cells as it is an antibody that gives specificity and targeting. The current major targets are CD19 to kill most B cells and we know this works in MS already in a few people where it has been done and we know that the cells get into the brain unlike antibodies.\u00a0 Another target\u00a0 is B cells maturation antigen on antibody producing cells.\u00a0 The way you get a CAR-T is you infect the T cells grow them in a test tube. You have to immunosuppress the individual. Now they have developed a way to do the infection in the body and this a technological advantage. They say NMO is driven by a certain type of cell the next thing is to target the cells that drive the disease. So you could kill aquaporin four specific cells you can kill EBV<\/p>\n<\/p>\n<p><em>Source: <a href=\"https:\/\/multiple-sclerosis-research.org\/2025\/10\/54216\/?utm_source=rss&#038;utm_medium=rss&#038;utm_campaign=54216\" rel=\"nofollow noopener\" target=\"_blank\">multiple-sclerosis-research.org<\/a><\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tweet I am often accused of being a glass half empty Yorkshireman and never sufficiently positive. But I think MS can learn from Lupus and it&#8217;s little cousin called neuromyelitis optica or historically Devics multiple sclerosis. CAR-T therapy where you make T cells target something else using a chimeric antigen receptor. Chimeric because the antigen&#8230;<\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[11,15,9,8,13,14,12,10],"class_list":["post-620","post","type-post","status-publish","format-standard","hentry","category-multiple-sclerosis-research","tag-brain-repair","tag-marburg-type-ms","tag-ms","tag-multiple-sclerosis","tag-myelin","tag-neuroregeneration","tag-oligodendrocyte","tag-remyelination"],"_links":{"self":[{"href":"https:\/\/wickedsister.evit.com.au\/index.php\/wp-json\/wp\/v2\/posts\/620","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wickedsister.evit.com.au\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wickedsister.evit.com.au\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/wickedsister.evit.com.au\/index.php\/wp-json\/wp\/v2\/comments?post=620"}],"version-history":[{"count":0,"href":"https:\/\/wickedsister.evit.com.au\/index.php\/wp-json\/wp\/v2\/posts\/620\/revisions"}],"wp:attachment":[{"href":"https:\/\/wickedsister.evit.com.au\/index.php\/wp-json\/wp\/v2\/media?parent=620"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wickedsister.evit.com.au\/index.php\/wp-json\/wp\/v2\/categories?post=620"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wickedsister.evit.com.au\/index.php\/wp-json\/wp\/v2\/tags?post=620"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}