{"id":621,"date":"2025-10-12T09:06:28","date_gmt":"2025-10-12T09:06:28","guid":{"rendered":"https:\/\/wickedsister.evit.com.au\/index.php\/2025\/10\/12\/recovery-takes-time\/"},"modified":"2025-10-12T09:06:28","modified_gmt":"2025-10-12T09:06:28","slug":"recovery-takes-time","status":"publish","type":"post","link":"https:\/\/wickedsister.evit.com.au\/index.php\/2025\/10\/12\/recovery-takes-time\/","title":{"rendered":"Recovery takes time"},"content":{"rendered":"<div class=\"twitter-share\"><a href=\"https:\/\/twitter.com\/intent\/tweet?url=https%3A%2F%2Fmultiple-sclerosis-research.org%2F2025%2F10%2Frecovery-takes-time%2F&#038;via=the_MSBlog\" class=\"twitter-share-button\" data-size=\"large\">Tweet<\/a><\/div>\n<p>I have got off on one about Progression independent of relapse as a measure of worsening. Here they look at time for worsening and it says you can recover over a long time.<\/p>\n<p>Mostert J, Strijbis EM, D&#8217;Haeseleer M, Moral E, Brieva L, Comtois J, Repovic P, Bowen JD, Cutter G, Koch M. Extended window of relapse recovery in RRMS: an analysis of the DECIDE dataset. J Neurol Neurosurg Psychiatry. 2025 Oct 9:jnnp-2025-336660. doi: 10.1136\/jnnp-2025-336660. Epub ahead of print. PMID: 41072954.<\/p>\n<p><strong class=\"sub-title\">Background:&nbsp;<\/strong>The main goal of treatment in relapsing-remitting multiple sclerosis (RRMS) is to reduce the occurrence of relapses. However, little is known about the natural history of relapse recovery.<\/p>\n<p><strong class=\"sub-title\">Methods:&nbsp;<\/strong>We accessed data from DECIDE (n=1841), a phase 3 trial. We investigated factors associated with time to relapse recovery (defined as a return of the Expanded Disability Status Scale (EDSS) score to the pre-relapse level or lower), relapse severity (0.5, 1.0, or &gt;1.0 EDSS score change) and the new concept of &#8216;acute clinical events with stable MRI&#8217; (ACES). Variables used were age, sex, disease duration, treatment arm, pre-relapse EDSS, corticosteroid use, number of relapses prior to study enrolment, MRI activity, relapse severity and affected functional system (FS).<\/p>\n<p><strong class=\"sub-title\">Results:&nbsp;<\/strong>We included 430 first relapses, of which 405 (94.2%) recovered during follow-up, 400 (93%) by 1 year (median time to recovery of 71 days, 95% CI 66 to 75 days). More severe relapses and relapses involving the bowel and bladder FS took a longer time to recover. Corticosteroids hastened the recovery of relapses but did not influence eventual relapse recovery. ACES occurred in 38% of relapses and was more frequent in older people and participants treated with daclizumab.<\/p>\n<p><strong class=\"sub-title\">Conclusions:\u00a0<\/strong>Most relapses (94.2%) recover, but the process of recovery can take upto 1 year and depends mostly on relapse severity. Our findings challenge the concept of 3-month and 6-month confirmed disability progression as reliable markers of permanent disability in RRMS trials. ACES occurs frequently and is associated with age<\/p>\n<p><em>Source: <a href=\"https:\/\/multiple-sclerosis-research.org\/2025\/10\/recovery-takes-time\/?utm_source=rss&#038;utm_medium=rss&#038;utm_campaign=recovery-takes-time\" rel=\"nofollow noopener\" target=\"_blank\">multiple-sclerosis-research.org<\/a><\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tweet I have got off on one about Progression independent of relapse as a measure of worsening. Here they look at time for worsening and it says you can recover over a long time. Mostert J, Strijbis EM, D&#8217;Haeseleer M, Moral E, Brieva L, Comtois J, Repovic P, Bowen JD, Cutter G, Koch M. Extended&#8230;<\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[11,15,9,8,13,14,12,10],"class_list":["post-621","post","type-post","status-publish","format-standard","hentry","category-multiple-sclerosis-research","tag-brain-repair","tag-marburg-type-ms","tag-ms","tag-multiple-sclerosis","tag-myelin","tag-neuroregeneration","tag-oligodendrocyte","tag-remyelination"],"_links":{"self":[{"href":"https:\/\/wickedsister.evit.com.au\/index.php\/wp-json\/wp\/v2\/posts\/621","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wickedsister.evit.com.au\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wickedsister.evit.com.au\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/wickedsister.evit.com.au\/index.php\/wp-json\/wp\/v2\/comments?post=621"}],"version-history":[{"count":0,"href":"https:\/\/wickedsister.evit.com.au\/index.php\/wp-json\/wp\/v2\/posts\/621\/revisions"}],"wp:attachment":[{"href":"https:\/\/wickedsister.evit.com.au\/index.php\/wp-json\/wp\/v2\/media?parent=621"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wickedsister.evit.com.au\/index.php\/wp-json\/wp\/v2\/categories?post=621"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wickedsister.evit.com.au\/index.php\/wp-json\/wp\/v2\/tags?post=621"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}