{"id":738,"date":"2025-10-30T02:10:24","date_gmt":"2025-10-30T02:10:24","guid":{"rendered":"https:\/\/wickedsister.evit.com.au\/index.php\/2025\/10\/30\/ebv-as-a-cause-in-children\/"},"modified":"2025-10-30T02:10:24","modified_gmt":"2025-10-30T02:10:24","slug":"ebv-as-a-cause-in-children","status":"publish","type":"post","link":"https:\/\/wickedsister.evit.com.au\/index.php\/2025\/10\/30\/ebv-as-a-cause-in-children\/","title":{"rendered":"EBV as a cause in Children"},"content":{"rendered":"<div class=\"twitter-share\"><a href=\"https:\/\/twitter.com\/intent\/tweet?url=https%3A%2F%2Fmultiple-sclerosis-research.org%2F2025%2F10%2Febv-as-a-cause-in-children%2F&#038;via=the_MSBlog\" class=\"twitter-share-button\" data-size=\"large\">Tweet<\/a><\/div>\n<p>EBV as the cause of MS&#8230;but that means everyone with MS has to be infected with EBV&#8230;one negative and &#8220;the&#8221; cause has to change to &#8220;a&#8221; cause. In most studies with children, the rate of EBV positivitiy seldom reached 100% but not in this study.  100% in MS, 59% in controls, 70% with headache&#8230;..so not all autoimmune individuals had EBV infection evidence so what is the mechanism mine is now less clear<\/p>\n<p>Monte G, Tiralongo G, Papetti L, Ferilli MAN, Proietti Checchi M, Voci A, Ruscitto C, Salvetti M, Bellucci G, Valeriani M. Complete Epstein-Barr virus seropositivity in a cohort of pediatric onset multiple sclerosis: a comparison to other autoimmune diseases. J Neurol. 2025 ;272(11):735.\u00a0<\/p>\n<p><strong>Introduction:&nbsp;<\/strong>The role of Epstein-Barr virus (EBV) in multiple sclerosis (MS) pathogenesis is supported by the increased MS risk after infectious mononucleosis. This study aimed to evaluate EBV infection in our pediatric-onset MS (POMS) cohort.<\/p>\n<p><strong>Methods:&nbsp;<\/strong>MS patients with disease onset &lt; 18 years of age seen at Bambino Ges\u00f9 Children&#8217;s Hospital were included. We searched for anti-EBV nuclear antigen (EBNA) Immunoglobulin G (IgG) and anti-viral capsid antigen (VCA) IgG and IgM. For comparison, we analyzed the EBV infection seroprevalence in an age- and sex-matched control cohorts of immunologically-healthy children and subjects with non-neurological autoimmune diseases.<\/p>\n<p><strong>Results:\u00a0Fifty-seven POMS were included; all<\/strong> had a previous EBV infection. The controls&#8217; cohort included one-hundred and sixty-two patients with a median age of 12 years (range 6-17), encompassing two subgroups: non-autoimmune (i.e. primary headaches) and autoimmune controls, namely inflammatory bowel disease and juvenile idiopathic arthritis. In the control group, ninety-six (59%) were EBV seropositive. EBV seropositivity was significantly higher in POMS than in the controls&#8217; cohort (OR = 79.2, 95% C.I. 4.8-1305), and compared to autoimmune and non-autoimmune controls separately (p &lt; 0.0001).<\/p>\n<p><strong>Discussion:\u00a0<\/strong>In our POMS cohort, <strong>EBV seropositivity was 100%, higher than previously reported<\/strong>. Our results support a disease-specific role of EBV in the MS development compared to other pediatric autoimmune disorders, consistent with evidence reported in adult-onset MS.<\/p>\n<p><em>Source: <a href=\"https:\/\/multiple-sclerosis-research.org\/2025\/10\/ebv-as-a-cause-in-children\/?utm_source=rss&#038;utm_medium=rss&#038;utm_campaign=ebv-as-a-cause-in-children\" rel=\"nofollow noopener\" target=\"_blank\">multiple-sclerosis-research.org<\/a><\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tweet EBV as the cause of MS&#8230;but that means everyone with MS has to be infected with EBV&#8230;one negative and &#8220;the&#8221; cause has to change to &#8220;a&#8221; cause. In most studies with children, the rate of EBV positivitiy seldom reached 100% but not in this study. 100% in MS, 59% in controls, 70% with headache&#8230;..so&#8230;<\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[11,15,9,8,13,14,12,10],"class_list":["post-738","post","type-post","status-publish","format-standard","hentry","category-multiple-sclerosis-research","tag-brain-repair","tag-marburg-type-ms","tag-ms","tag-multiple-sclerosis","tag-myelin","tag-neuroregeneration","tag-oligodendrocyte","tag-remyelination"],"_links":{"self":[{"href":"https:\/\/wickedsister.evit.com.au\/index.php\/wp-json\/wp\/v2\/posts\/738","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wickedsister.evit.com.au\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wickedsister.evit.com.au\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/wickedsister.evit.com.au\/index.php\/wp-json\/wp\/v2\/comments?post=738"}],"version-history":[{"count":0,"href":"https:\/\/wickedsister.evit.com.au\/index.php\/wp-json\/wp\/v2\/posts\/738\/revisions"}],"wp:attachment":[{"href":"https:\/\/wickedsister.evit.com.au\/index.php\/wp-json\/wp\/v2\/media?parent=738"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wickedsister.evit.com.au\/index.php\/wp-json\/wp\/v2\/categories?post=738"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wickedsister.evit.com.au\/index.php\/wp-json\/wp\/v2\/tags?post=738"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}