{"id":821,"date":"2025-11-15T17:44:00","date_gmt":"2025-11-15T17:44:00","guid":{"rendered":"https:\/\/wickedsister.evit.com.au\/index.php\/2025\/11\/15\/crap-gap\/"},"modified":"2025-11-15T17:44:00","modified_gmt":"2025-11-15T17:44:00","slug":"crap-gap","status":"publish","type":"post","link":"https:\/\/wickedsister.evit.com.au\/index.php\/2025\/11\/15\/crap-gap\/","title":{"rendered":"Crap Gap"},"content":{"rendered":"<div class=\"twitter-share\"><a href=\"https:\/\/twitter.com\/intent\/tweet?url=https%3A%2F%2Fmultiple-sclerosis-research.org%2F2025%2F11%2Fcrap-gap%2F&#038;via=the_MSBlog\" class=\"twitter-share-button\" data-size=\"large\">Tweet<\/a><\/div>\n<p>I was at a meeting recently and they started talking about the wearing -off effect&#8230;some people piped up that it was all in the minds of some people and that when you do a proper controlled study as opposed to listening to Mr\/Mrs Big Mouth then people can&#8217;t find any thing different but others say there are too many people you say the same thing that they feel like they know when they need the next dose&#8230;One MSers I know said when they were taking natalizumab that they knew when their MS-coke needed a top-up. What is the wearing off effect and what is the biology?. I thought it must be a cytokine thing creating a fatigue, but hey what do I knoe What do you think<\/p>\n<p>Gelissen LMY, Hogenboom L, Toorop AA, Strijbis EMM, van Oosten BW, de Jong BA, Killestein J, van Kempen ZLE. Wearing-off symptoms persist in the majority of patients with multiple sclerosis after switching from natalizumab to ocrelizumab. J Neurol Sci. 2025 Nov 10;479:125652<\/p>\n<p><strong>Background:&nbsp;Wearing-off symptoms<\/strong> (WoS) are common in multiple sclerosis (MS) patients treated with biologicals.<\/p>\n<p><strong>Objectives:&nbsp;<\/strong>To investigate the occurrence of WoS in patients with MS who switch from natalizumab to ocrelizumab treatment.<\/p>\n<p><strong>Methods:&nbsp;<\/strong>We evaluated WoS in patients who completed a WoS questionnaire during both natalizumab and ocrelizumab treatment.<\/p>\n<p><strong>Results:&nbsp;<\/strong>Among the included patients (N = 33), those with WoS during natalizumab treatment had higher odds of experiencing WoS during subsequent ocrelizumab treatment, compared to those without WoS during natalizumab treatment.<\/p>\n<p><strong>Conclusions:&nbsp;<\/strong>These findings could be valuable for patient counselling, though validation in a larger cohort is desired.<\/p>\n<p><em>Source: <a href=\"https:\/\/multiple-sclerosis-research.org\/2025\/11\/crap-gap\/?utm_source=rss&#038;utm_medium=rss&#038;utm_campaign=crap-gap\" rel=\"nofollow noopener\" target=\"_blank\">multiple-sclerosis-research.org<\/a><\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tweet I was at a meeting recently and they started talking about the wearing -off effect&#8230;some people piped up that it was all in the minds of some people and that when you do a proper controlled study as opposed to listening to Mr\/Mrs Big Mouth then people can&#8217;t find any thing different but others&#8230;<\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[11,15,9,8,13,14,12,10],"class_list":["post-821","post","type-post","status-publish","format-standard","hentry","category-multiple-sclerosis-research","tag-brain-repair","tag-marburg-type-ms","tag-ms","tag-multiple-sclerosis","tag-myelin","tag-neuroregeneration","tag-oligodendrocyte","tag-remyelination"],"_links":{"self":[{"href":"https:\/\/wickedsister.evit.com.au\/index.php\/wp-json\/wp\/v2\/posts\/821","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wickedsister.evit.com.au\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wickedsister.evit.com.au\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/wickedsister.evit.com.au\/index.php\/wp-json\/wp\/v2\/comments?post=821"}],"version-history":[{"count":0,"href":"https:\/\/wickedsister.evit.com.au\/index.php\/wp-json\/wp\/v2\/posts\/821\/revisions"}],"wp:attachment":[{"href":"https:\/\/wickedsister.evit.com.au\/index.php\/wp-json\/wp\/v2\/media?parent=821"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wickedsister.evit.com.au\/index.php\/wp-json\/wp\/v2\/categories?post=821"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wickedsister.evit.com.au\/index.php\/wp-json\/wp\/v2\/tags?post=821"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}