Happy Friday Eve, y’all! I hope you are doing well, and the week has treated you well. It has been a while since my last post, and I had promised myself I would write more, but too many things have gotten in the way. When I do write something, I am sharing it with others,…
EBV the target
Tweet Meloni C, Marnetto F, Fagnani C, Benincasa L, Galano D, Trivedi P, Valentino P, Martire S, Di Sapio A, Bertolotto A, Repice AM, Ballerini C, Mancosu C, Frau J, Cocco E, Veroni C. EBV Dysregulation Is Associated With Immune Imbalance in Multiple Sclerosis: Evidence From Integrated Viral and Host Analyses. Neurol Neuroimmunol Neuroinflamm. 2026…
New study connects immune cell behavior to Mavenclad response in MS
A new study suggests that how certain immune cells respond to Mavenclad (cladribine) may help explain why the treatment works well for some people with multiple sclerosis (MS), but less so for others. The researchers found that regulatory T-cells, or Tregs — immune cells that normally help keep inflammation in check — are relatively resistant…
Partners to provide Mayzent access for SPMS patients in Canada
Teva Canada and Novartis Canada formed a partnership to ensure continued access to Mayzent (siponimod) for people in Canada living with active secondary progressive multiple sclerosis (SPMS). Teva Canada will take over the promotion, distribution, and commercialization of the oral MS therapy in Canada. The companies say the collaboration is intended to support patients and…
Well Done..You Did it.
Tweet This is a study to determine whether you can follow instructions at home. Yep it concludes that you are big boys and girls and can follow instructions to look after you own health. Well done. Well is it surprising as people have been taking medicines at home for along time. This study looks at…
B cell follicles as a central problem for the cause of Brain Damage
Tweet Lymphotoxin-dependent elevated meningeal 1 CXCL13:BAFF ratios drive grey matter injury, Nature Immunology (2026). DOI: 10.1038/s41590-025-02359-5 CXCL13 (C-X-C motif chemokine ligand 13) is a chemokine (a molecule that cells migrate towards) that acts as a B-cell attractant, guiding their movement and organizing immune responses, especially in lymphoid tissues. It binds to the CXCR5 receptor (high on B cells and…
BTK inhibitors match Aubagio at reducing relapse rates in MS: Review
Experimental Bruton’s tyrosine kinase (BTK) inhibitors, such as tolebrutinib or evobrutinib, are as effective as the approved therapy Aubagio (teriflunomide) at preventing relapses in people with relapsing forms of multiple sclerosis (MS), according to a review of published studies. The review found the therapies to be equally safe. BTK inhibitors are better at delaying short-term…
Warning signs of multiple sclerosis may surface years before diagnosis
Years before a diagnosis of multiple sclerosis (MS), people who later develop the disease have more doctor visits and hospitalizations for sensory, nervous system, and muscle problems than people in the general population, according to a recent study. The findings support the idea of an early phase of MS, known as the prodromal phase, when…
Time for me to Eat SH1?
Tweet Here we a have a case report of a lady who has tried a number of disease modifying treatments which were all discountinued due to lack of effect and side effects. They had been drug free for a decade and no MRI lesions but had longstanding gastrointestinal problems including smelly boffs, cramps and continence…
Shana Stern – MSAA’s February 2026 Artist of the Month
MSAA features the work of many talented artists affected by multiple sclerosis as part of our annual MSAA Art Showcase. Each month we share these artists’ inspiring stories and beautiful artwork with you as our Artist of the Month. This month, we celebrate Shana Stern as February’s … Continue reading → Source: blog.mymsaa.org