Tweet Natalizumab exchanges its arms so the left arm doesn’t know what the right arm is doing. When an IgG1 antibody is made it has two arms called Fragment Antigen Binding or Fab. Each arm of the Fab binds to the same target so they…
Tweet This study uses high end technology to delve into the “unclear” and the conclusion is that cladribine gives long-term depletion of memory B cells and then we can say “Should have gone to spec savers” to read our papers from about a decade go.…
The first night after my husband, Rhead, moved into an assisted living facility, I stood in our kitchen and listened to how quiet the house was. Our six kids were asleep, the dog was asleep, and I was alone with a silence I hadn’t heard…
Tweet ProfK is a CladLad and has been flying the flag for many years. I put this paper up as it reinforces what I was saying about breaks after anti-CD20. Someone asked me if we will ever get a chemical B cell depleters. My answer…
Tweet Hear it from the pulpit, on this occasion set up at The Royal Society: Disclosure (from today’s blogger): Professor Coles chairs the DMEC of ChariotMS (NCT04695080), a trial of cladribine in people with advanced MS, which is supported by the MS Society as part…
When Jennifer and I launched the podcast for A Couple Takes on MS, we hoped it would spark honest conversations about life with Multiple Sclerosis, caregiving, advocacy, and marriage. We did not expect it to become such an important part of our lives. Now, more…
Keep your kitchen cool this Memorial Day weekend with some simple side dish options requiring zero cooking or grilling. These fresh, colorful side dishes take less than 10 minutes to whip up and bring a bright crunch to your holiday … Continue reading → Source:…
Using psychoactive drugs such as alcohol, caffeine, nicotine, cannabis, or opioids may help ease certain symptoms of multiple sclerosis (MS) — but many of these substances can make other MS symptoms worse, a study found. The researchers also found that the specific symptoms a patient…
Tweet Schoof LG, Hogenboom L, van Kempen ZL, Killestein J, van Oosten BW, Strijbis EM. Reinitiating ocrelizumab with a full 600 mg dose after extended treatment interruption: No increased risk of infusion-related reactions. Mult Scler J Exp Transl Clin. 2026 May 15;12(2):20552173261449688. You can get infusion…
In a column I wrote a couple years ago, I noted that, despite my fascination with the subject of psychology, I have only an amateur understanding of it. We can add artificial intelligence (AI) to the long list of things I’m not an expert on.…