Park B, Nicaise AM, Tsitsipatis D, Pirvan L, Zucha D, Munteanu A, Prasad P, De Novales MLL, Bulgaru C, Kollyfas R, Whitten J, Willis CM, Culig L, Llewellyn J, Ionescu RB, Mekdad M, Simões-Abade MBC, Krzak G, Fan J, De S, Ellis MO, Cubero MS, Spathopoulou A, Peruzzotti-Jametti L, Leonardi T, Balmus G, Edenhofer F, Gorospe M, Valihrach L, Mohorianu I, Pluchino S, Beerman I. Integrated omics reveals disease-associated radial glia-like cells with epigenetically dysregulated interferon response in multiple sclerosis. Neuron. 2025 Oct 10:S0896-6273(25)00710-X.
Progressive multiple sclerosis (PMS) involves a persistent, maladaptive inflammatory process with numerous cellular drivers……..Single-cell multi-omics uncovered a novel, disease-associated radial glia-like cell (DARG) subpopulation in PMS cell lines exhibiting senescence (aging) and potent intererfon responsiveness driven by specific transcription factors. Functionally, PMS induced Neural stem cells induced ………… inflammation onto control cells, which was inhibited upon senolytic treatment……… DARGs may sustain smoldering inflammation, unveiling a previously unrecognized cellular axis that could underpin mechanisms in neurodegeneration. This discovery offers novel insights into disease mechanisms and highlights potential therapeutic targets.
Smoldering inflammation is thought to be at the root of progressive MS and this study aims to examine the drivers of this process and by making neural stem cells thhat carry the signature of gnes being regulated in the individual, it was suggested that a subset of glial responses may be as a root cause of the problem.
The amount of information in the publication is staggering and so much so that it is overwhelmoiing for the causal read and it will take alot of effort to digest this.It suggests that there is a type of glial cell as central player in progression. I will take this on face value. We will have to see it it leads to a solution, but if you know where you are looking it may help
COI None
Source: multiple-sclerosis-research.org