Tweet One of the readers asked about anti-EBV trials and I would say there are loads of them and this one from Oz popped up like some social media listening and sending device. Personally I think these “we are doing a trial” papers are a waste of space but ProfK is doing them for chariotMS…
Month: December 2025
A relapse showed me that trying to ‘prove’ my MS doesn’t work
This year has been a lot for me to deal with. It’s held more grief, trauma, and growing pains for me than any year before it. And it all started with a relapse of my relapsing-remitting multiple sclerosis (RRMS) that came after nearly nine years of remission following my hematopoietic stem cell transplant. With that…
EBV and T cells..Should I mean B cells
Tweet So far 233 common genome loci have been associated with disease risk and one variant associated with disease progression. The majority of these map to the immune system, targeting T cells, regulatory T cells, and, in particular, B cells. Here, they analyzed 617,186 participants applying harmonized viral-detection across 108 ancestries. They identified 39 susceptibility…
You get a Dictionary for CHristmas
Tweet Here is something you can spend a week or more to decipher, they took cells from 12 people and stimulated them with cell messengers and saw what they produce…They they dividied the cells up into different T types and for the T cell followers you get your cake and you can eat it but…
Learning and dancing the steps of caregiving together
Caregiving couples like Jennifer and me perform a dance every day that no one ever teaches you. There’s no studio. No choreography sheet. No one calling out the counts. And yet, somehow, we learn the steps through repetition, trust, and a ton of trial and error. Photo by Emily Mesner Honestly, it probably deserves a…
🎄Holiday Thoughts🎅
The holiday season is supposed to be a time of togetherness, kindness, and appreciation. For so many, it is a happy time with their families, but unfortunately, for too many, it is a sad time for various reasons. Even though it is the holiday season, many people are still fighting for their lives and suffering from…
Four distinct paths of disability progression emerge in relapsing MS
Disability progression in relapsing forms of multiple sclerosis (MS) tends to follow one of four distinct patterns, according to long-term data from more than 5,000 people with relapsing-onset MS followed in an Italian registry. The study specifically found that disability progression could generally be categorized into four patterns: minimal-worsening, late-worsening, early-worsening, and rapid-worsening. Although all…
B cell depleting antibodies block COVID-19 vaccination even after three rounds.
Tweet As we edge towards chrimbo day, I thought I would give you this info that people on B cell depleting antibodies make a blunted/limited vaccine response and this persists up to three rounds of vaccine. I guess this is a bit of a NSS moment….We reported the issue of blunting of vaccine response in…
Wishes, A Story and a Hymn, MS Style
A little MS holiday card for you Merry Christmas! Blessed Hanukkah! Joyous Kwanzaa! And a most Happy 2026 to all of you!!! As happens far too often, like every year, the holidays have snuck up on me yet again. I am so very thankful to all of you, my readers and appreciate you immensely. I…
Experimental MS therapy reinforces ‘brakes’ on overactive T-cells
Immutep’s experimental immunotherapy, IMP761, continues to demonstrate a favorable safety profile, along with sustained suppression of T-cell activity, immune cells that are overly active in multiple sclerosis (MS) and other autoimmune diseases. These findings are based on data from healthy people enrolled in an ongoing first-in-human Phase 1 trial (NCT06637865), who received single doses of IMP761…