People exposed to higher levels of certain manufactured compounds that persist in the environment are more likely to be diagnosed with multiple sclerosis (MS), a new study reports. A higher MS risk was associated with elevated levels of PFAS, also known as “forever chemicals,” and specific metabolites of PCBs, which have been banned in many…
Month: December 2025
CD20 depletion is over dosing based on rituximab
Tweet Eight years ago we suggested that anti-CD20 depleting antibodies may act for much longer than the dosing and suggested that it may be possible to use like alemtuzumab and cladribine and then we provided supportive evidence from the phase II study whereby efficacy was maintained for 18 months after stopping ocrelizumab which suggested that…
Dizzy and the Little Christmas Ghost
Once there was a little donkey called Dizzy. Dizzy lived in a quiet, snowy place where the nights grew long at Christmas, and the stars felt very close to the ground. She was a kind donkey, though sometimes a little mischievous. She liked the gentle things in life, gingernut biscuits, ginger biscuits, and the smell…
Fear of MS relapse, progression drives anxiety for patients: Study
Fear of a sudden relapse or a gradual worsening of MS symptoms is common among people with multiple sclerosis (MS), according to a systematic review analyzing data from more than 3,000 people with MS. Those fears are not only widespread but also closely tied to poorer mental health, greater fatigue, and reduced quality of life, the…
Wrapping Up
2025 has been a memorable year. As the year sped by, it is worth reflecting and remembering both the good and the bad moments. It gives me an opportunity to assess the flaws on my side and a chance to … Continue reading → Source: blog.mymsaa.org
Neurofilament. Which assay do you use to assay it.
Tweet The sugestion is that they are all more or less the same. Here I think that this is good but one wonders when this will be a standard diagnostic test not run be a few labs. It should be a bog standard test. This depends on the access to the machines Dargvainiene J, Torge…
The medusa wins and Perseus is turned to primary progressive stone.
Tweet Tolebrutinib is a Brutons Tyrosine Kinase inhibitor and it failed to inhibit relapsing MS in trials compared to teriflunomide and now it has failed to inhibit progression in primary progressive MS in the PERSEUS trial…..so is there a future for tolebrutinib in non relapsing progressive MS? It has been approved in the Middle East…
Lipoic Acid 1-1..A positive and now a negative
Tweet Lipoic acid is the drug of hope in OCTOPUS trial because there was supportive evidence from trials in progressive MS in humans. However, this hope is being dashed by this recent trial. Lipoic acid wasn’t good enough in the trial, but was the trial good enough to show an effect of lipoic acid. This…
Let It Go Friday!
Happy Friday, y’all! I hope you have had a good week and you are ready for a weekend filled with what brings you the most happiness. It has been a while since I have written a post, as I have been very preoccupied. It is the week before Christmas, and I am still far from…
Highlighting the MS Community This Holiday Season and Always
As we approach the season of giving, the Multiple Sclerosis Association of America (MSAA) would like to bring special attention to the many wonderful community members that we serve. With our mission of Improving Lives Today, MSAA genuinely strives to … Continue reading → Source: blog.mymsaa.org