This morning I woke up like someone has been punching me in the arm all night and guess it is all related to neck problems but it is part of that dropping to bits as you get older thing.
Toss on top of this multiple sclerosis and you have a neurodegenerative condition (MS) and a (neuro)degenerative condition. So not surprisingly if you develop MS later in life, you are not going to recover from injury as well as you did when you were younger…OK queue Tai Chi Youtube advert…Running breaks joints..Tai Chi gives you a six pack…ollocks.
This study is simply using MSBase to get information on a big scale of what we think we already know so is a bit NSS but lets you log the fact and put it to bed. Likewise children are often more resilient
Souissi A, Patti F, Spelman T, Chisari C, Gargouri A, John N, Kermode AG, Kalincik T, Butzkueven H, Sajedi SA, Lechner-Scott J, Roos I, Laureys G, Taylor B, Alroughani R, Khoury SJ, Macdonell R, Weinstock-Guttman B, Havrdova EK, Maimone D, Reddel S, Fabis-Pedrini M, Willekens B, Moghadasi AN, Lalive P, Lugaresi A, Ozakbas S, Solaro C, Cárdenas-Robledo S, Shaygannejad V, Etemadifar M, Boz C, Eichau S, Tomassini V, Terzi M, Prat A, Habek M, Blanco Y, Altintas A, Gerlach O, Turkoglu R, Buzzard K, Skibina O, Soysal A, van der Walt A, Hughes S, van Pesch V, Foschi M, Surcinelli A, Prevost J, Ramo-Tello C, McGuigan C, Sa MJ, Kuhle J, Spitaleri D, Singhal B, Ampapa R, de Gans K, Petersen T, Simu M, Lapointe E, Sanchez-Menoyo JL, Gray O, Garber J, Aguera-Morales E, Gross-Paju K, Castillo-Triviño T, Al-Asmi A, Grigoriadis N, Inshasi J, Al-Harbi T, Hardy TA, Ramanathan S, Cambron M, Shuey N, Sempere AP, Csepany T, Treviño-Frenk I, Rozsa C, Cauchi M, Karabudak R, Mrabet S, Gouider R. Effect of late-onset on multiple sclerosis phenotype and outcome: evidence from a multi-national registry. J Neurol. 2026 Feb 4;273:114.
Background: Multiple Sclerosis (MS) severity is influenced by several factors. Understanding the impact of age at disease onset may help to better characterize clinical and disease features across age groups. This study aimed to characterize the clinical features and disability outcomes of late-onset MS (LOMS) and very late-onset MS (vLOMS), compared to adult-onset MS (AOMS).
Methods: We conducted an observational study using data from the MSBase registry and categorized patients based on age at MS onset: AOMS (18-39 years), transition onset (40-49 years), LOMS (50-59 years), and vLOMS (≥ 60 years). Disease progression was assessed using the 24 week confirmed disability progression, EDSS4 and 6 milestones, conversion to secondary progressive MS(SPMS), and the first progression independent of relapse activity (PIRA) event. Cox proportional hazard regression models were used to determine unadjusted hazard ratios(HR), and propensity score inverse probability of treatment weighting(PS-IPTW) balanced covariate distributions.
Results: Among 81,236 patients, 5.2% had LOMS and 1% had vLOMS. Primary progressive MS was more frequent in LOMS and vLOMS (21.7 and 24%, respectively). Patients with LOMS and vLOMS had a significantly increased risk of 24 week confirmed disability progression (HR:LOMS = 1.39, vLOMS = 1.80), EDSS 4 (HR:LOMS = 2.14, vLOMS = 2.95), EDSS 6 (HR:LOMS = 2.33, vLOMS = 6.33), SPMS (HR:LOMS = 1.62, vLOMS = 2.38), and first PIRA event (HR:LOMS = 2.12, vLOMS = 2.93).
Conclusion: LOMS and vLOMS exhibited a more progressive disease onset and higher disability milestones compared with AOMS.
Source: multiple-sclerosis-research.org