mmmmM…my favourite subject….Yep my Bad…I don’t know the back end of a flagelleum from the front end…So I will do like every respecting cheat and use AI rather than reading and ask it to tell me what the important bacteria in MS are. Here is the answer (from Google)
“Multiple sclerosis (MS) is associated with imbalances in gut microbiota and specific bacteria that may trigger CNS inflammation, particularly Akkermansia muciniphila, Acinetobacter calcoaceticus, Eisenbergiella tayi, and Lachnoclostridium. Epsilon toxin-producing Clostridium perfringens is linked to MS relapses, while Chlamydia pneumoniae has been found in the cerebrospinal fluid of patients.
Zhu F, Zhao Y, Arnold DL, Bar-Or A, Bernstein CN, Bonner C, Graham M, Hart J, Knox N, Marrie RA, Mirza AI, O’Mahony J, Van Domselaar G, Yeh EA, Banwell B, Waubant E, Tremlett H; US Network of Pediatric MS Centers, the Canadian Pediatric Demyelinating Disease Network. A cross-sectional study of MRI features and the gut microbiome in pediatric-onset multiple sclerosis. Ann Clin Transl Neurol. 2024; 11::486-496
Objective: To identify gut microbiome features associated with MRI lesion burden in persons with pediatric-onset multiple sclerosis (symptom onset <18 years).
Methods: A cross-sectional study involving the Canadian Paediatric Demyelinating Disease Network study participants. Gut microbiome features (alpha diversity, phylum- and genus-level taxa) were derived using 16S rRNA sequencing from stool samples. T1- and T2-weighted lesion volumes were measured on brain MRI obtained within 6 months of stool sample procurement. Associations between the gut microbiota and MRI metrics (cube-root-transformed) were assessed using standard and Lasso regression models.
Results: Thirty-four participants were included; mean ages at symptom onset and MRI were 15.1 and 19.0 years, respectively, and 79% were female. The T1- and T2-weighted lesion volumes were not significantly associated with alpha diversity (age and sex-adjusted p > 0.08). …High Tenericutes (relative abundance) was associated with higher T1 and T2 volumes…and high Firmicutes, Patescibacteria or Actinobacteria with lower lesion volumes……. High Ruminiclostridium, whereas low Coprococcus 3 and low Erysipelatoclostridium were associated with higher lesion volumes.
Interpretation: Our study characterized the gut microbiota features associated with MRI lesion burden in paediatric-onset MS, shedding light onto possible pathophysiological mechanisms.
I wonder why it is not consistent maybe you can enlighten me
Source: multiple-sclerosis-research.org