I have a bit of a laugh at the risk factor for MS of the week,which surfaces in this or that rag each week,
This week we had a new risk factor and that is food processed but here in another one and that is facial aging ….. what next anal bleaching:-)?
I did a social media course the other week and I know that I would get slapped wrists for that one but don’t choke on you rice crispies for breakfast. It’s only ABIT of fun.
Facial aging is becoming a wrinkley, but surely if you have abit of fat in your face you look better. This paper argues for facial aging as risk factor for obese people, I mean the other way round, but here MS is a risk factor for facial aging. So the next time you see someone on weight loss drugs are you going to think they have MS. Wieght and disease are so interlinked and so so it is always very hard to really know where to put the emphasis. However it allows the media to grab a health line or the opportunity for some pseudo science on a TV programme.
Lian J, Zhang Z, Yang W, Pan L, Pan X, Shao Y. Exploring the Causal Relationship and Potential Mediating Mechanisms Between Obesity and Facial Aging: A Two-Sample, Multivariable and Mediation Mendelian Randomization Study. Clin Cosmet Investig Dermatol. 2026 ;19:565342.
Purpose: Obesity is well established as a key contributor to multiple age-related diseases; however, its impact on facial aging (FA) remains equivocal. We aimed to elucidate the causal effects of various obesity phenotypes on FA with gender- and age-specific attention, as well as determine the potential mediating mechanisms in these relationships.
Results: …..Higher genetically predicted BMI was associated with accelerated FA…..Furthermore, several factors, including myocardial infarction, smoking, and premature menarche (menopause), were identified as independent risk factors for FA, independent of high BMI. Myocardial infarction, daily smoking, ischemic stroke, and multiple sclerosis were also found to mediate the causal relationship between BMI and FA partially.
Conclusion: Our study reveals distinct and significant variations in the effects of different obesity phenotypes on the acceleration of FA, with these effects exhibiting gender- and age-specific patterns. The findings underscore the critical importance of weight management as a potential intervention for mitigating FA.
Source: multiple-sclerosis-research.org