Featuring Barry A. Hendin, MD MSAA’s Chief Medical Officer Barry Hendin, MD Question: What should care partners do if they suspect depression in their loved one with MS, and what are the treatment options? Answer: Like other medical illnesses, depression … Continue reading → Source: blog.mymsaa.org
Category: Multiple Sclerosis Research
FDA denies tolebrutinib approval for nonrelapsing progressive MS
After months of delay, the U.S. Food and Drug Administration (FDA) has rejected Sanofi‘s application seeking approval of tolebrutinib for the treatment of adults with nonrelapsing secondary progressive multiple sclerosis (MS). While Sanofi announced earlier this month that the decision was likely to be delayed again and that further guidance from the FDA was expected…
The 72 hours I borrow my body back
The hardest part of my Multiple Sclerosis Rituxan infusion isn’t the struggle to find a plump vein for an IV placement, or the five hours Dan and I spend in the infusion center, or even the fatigue that follows. The hardest part is the dose of Solu-Medrol that the nurses give me before my treatment…
Anti-Lingo Trial
Tweet This work was done and completed years ago and the take home message is that the results weren’t good enough of it to be developed. Lingo-1 is part of the pathway that prevents nerve regeneration , but it was also reported to inhibit remyelination. In early trials that was dose ranging dosing up to…
Emergency-Paging Dr.K
Tweet OK its not Dr Beat its ProfK. They “argue that despite significant advances in MS immunotherapy, and framework ideas to prevent the disease altogether, MS clinicians, let alone the general neurology community, regularly fails to make effective use of secondary preventive strategies. Clinical practice remains conservative. Many patients start treatment months—or even years—after diagnosis,…
EBV trials
Tweet One of the readers asked about anti-EBV trials and I would say there are loads of them and this one from Oz popped up like some social media listening and sending device. Personally I think these “we are doing a trial” papers are a waste of space but ProfK is doing them for chariotMS…
A relapse showed me that trying to ‘prove’ my MS doesn’t work
This year has been a lot for me to deal with. It’s held more grief, trauma, and growing pains for me than any year before it. And it all started with a relapse of my relapsing-remitting multiple sclerosis (RRMS) that came after nearly nine years of remission following my hematopoietic stem cell transplant. With that…
EBV and T cells..Should I mean B cells
Tweet So far 233 common genome loci have been associated with disease risk and one variant associated with disease progression. The majority of these map to the immune system, targeting T cells, regulatory T cells, and, in particular, B cells. Here, they analyzed 617,186 participants applying harmonized viral-detection across 108 ancestries. They identified 39 susceptibility…
You get a Dictionary for CHristmas
Tweet Here is something you can spend a week or more to decipher, they took cells from 12 people and stimulated them with cell messengers and saw what they produce…They they dividied the cells up into different T types and for the T cell followers you get your cake and you can eat it but…
Learning and dancing the steps of caregiving together
Caregiving couples like Jennifer and me perform a dance every day that no one ever teaches you. There’s no studio. No choreography sheet. No one calling out the counts. And yet, somehow, we learn the steps through repetition, trust, and a ton of trial and error. Photo by Emily Mesner Honestly, it probably deserves a…