The holiday season is supposed to be a time of togetherness, kindness, and appreciation. For so many, it is a happy time with their families, but unfortunately, for too many, it is a sad time for various reasons. Even though it is the holiday season, many people are still fighting for their lives and suffering from…
Four distinct paths of disability progression emerge in relapsing MS
Disability progression in relapsing forms of multiple sclerosis (MS) tends to follow one of four distinct patterns, according to long-term data from more than 5,000 people with relapsing-onset MS followed in an Italian registry. The study specifically found that disability progression could generally be categorized into four patterns: minimal-worsening, late-worsening, early-worsening, and rapid-worsening. Although all…
B cell depleting antibodies block COVID-19 vaccination even after three rounds.
Tweet As we edge towards chrimbo day, I thought I would give you this info that people on B cell depleting antibodies make a blunted/limited vaccine response and this persists up to three rounds of vaccine. I guess this is a bit of a NSS moment….We reported the issue of blunting of vaccine response in…
Wishes, A Story and a Hymn, MS Style
A little MS holiday card for you Merry Christmas! Blessed Hanukkah! Joyous Kwanzaa! And a most Happy 2026 to all of you!!! As happens far too often, like every year, the holidays have snuck up on me yet again. I am so very thankful to all of you, my readers and appreciate you immensely. I…
Experimental MS therapy reinforces ‘brakes’ on overactive T-cells
Immutep’s experimental immunotherapy, IMP761, continues to demonstrate a favorable safety profile, along with sustained suppression of T-cell activity, immune cells that are overly active in multiple sclerosis (MS) and other autoimmune diseases. These findings are based on data from healthy people enrolled in an ongoing first-in-human Phase 1 trial (NCT06637865), who received single doses of IMP761…
Exposure to PFAS and PCB mixtures linked to higher MS risk
People exposed to higher levels of certain manufactured compounds that persist in the environment are more likely to be diagnosed with multiple sclerosis (MS), a new study reports. A higher MS risk was associated with elevated levels of PFAS, also known as “forever chemicals,” and specific metabolites of PCBs, which have been banned in many…
CD20 depletion is over dosing based on rituximab
Tweet Eight years ago we suggested that anti-CD20 depleting antibodies may act for much longer than the dosing and suggested that it may be possible to use like alemtuzumab and cladribine and then we provided supportive evidence from the phase II study whereby efficacy was maintained for 18 months after stopping ocrelizumab which suggested that…
Dizzy and the Little Christmas Ghost
Once there was a little donkey called Dizzy. Dizzy lived in a quiet, snowy place where the nights grew long at Christmas, and the stars felt very close to the ground. She was a kind donkey, though sometimes a little mischievous. She liked the gentle things in life, gingernut biscuits, ginger biscuits, and the smell…
Fear of MS relapse, progression drives anxiety for patients: Study
Fear of a sudden relapse or a gradual worsening of MS symptoms is common among people with multiple sclerosis (MS), according to a systematic review analyzing data from more than 3,000 people with MS. Those fears are not only widespread but also closely tied to poorer mental health, greater fatigue, and reduced quality of life, the…
Wrapping Up
2025 has been a memorable year. As the year sped by, it is worth reflecting and remembering both the good and the bad moments. It gives me an opportunity to assess the flaws on my side and a chance to … Continue reading → Source: blog.mymsaa.org