Setting goals is easy, but holding ourselves accountable is where the real work begins. We often imagine that achieving a goal is simply about motivation, but it also involves structure, self-awareness, and creating the right environment. Accountability isn’t about pressure … Continue reading → Source: blog.mymsaa.org
When you know the stereotyped repopulation….you get what you get
Tweet This study looks at what happens after cladribine, which is more of less the same as happens with alemtuzumab and HSCT but perhaps with different kinetics. when you deplete a B cell with anti-CD20 depleter, alemtuzumab and cladribine the circulating naive and memory cells disappear and the memory cells stay disappeared and the naive…
To my brother, gone 19 years too many
I still miss your quiet support when you guided me when I needed strength. You were more than a brother; you were my first hero, a steady presence in my life, an unspoken promise that you’d always have my back. Source: irelandms.com
Should we be JC vaccinating
Tweet JC virus is a common virus and in most cases non-immunosuppressed make an immune response to the virus and keep it in check. However if you are immunosuppressed there is a risk that the virus escapes control and PML develops. There has been some benefit if you take the brakes off immune control and…
Extended Interval Dosing…When will it happen?…Do a pregnancy study
Tweet We have made a suggestion that cladribine, alemtuzumab and anti-CD20 depleters work in the same way and this would suggest that if you dose 3 times (i.e. a year) then you may be able to “watch and wait” just like you do with alemtuzumab and cladribine. This study asks what happens when you stop…
Pursuing quieter, more compassionate examples of self-care
Self-care is often framed as something luxurious, such as spa days, vacations, quiet mornings with coffee, and a to-do list that magically completes itself. But self-care looks different for everyone, especially those who are navigating chronic stress, illness, or caregiving. Living with relapsing-remitting multiple sclerosis, I’ve learned that self-care is often quieter for me: reading…
Dissolvable film may deliver more MS medicine than standard tablets
Bionxt Solutions’ experimental sublingual therapy BNT23001 led to about 40% higher blood exposure to cladribine than a conventional oral tablet formulation, such as those used in multiple sclerosis (MS) therapies like Mavenclad, the company reported. The results come from a preclinical study in adult miniature pigs, an animal model often used in drug research. Bionxt…
Easy Overnight Oats
Making overnight oats is simple and doesn’t require any cooking! This basic recipe can be customized to your liking with various add-ins and flavors. Ingredients: one serving, combine the following in a jar or airtight container: Instructions Source: blog.mymsaa.org
Impact from a trip to Portugal
Tweet In about 2016 ProfG asked MD to go to a conference in Lisbon to talk about how antibodies work in MS. He supplied about 80 slides for a 20minute talk. To be honest the conference was for antibody engineers who didn’t really care about MS and so maybe a reason why ProfG asked MD…
Targeting EBV-infected B-cells may help prevent or treat MS: Study
When immune B-cells mistakenly recognize the body’s own nerve tissue, they can shut themselves down to prevent damage, but infection with the Epstein-Barr virus (EBV) can trick B-cells into surviving and becoming activated in the brain instead of being eliminated by normal immune safety mechanisms, according to a study. These self-reactive B cells can then…