A brain protein called anoctamin-2 (ANO2) has emerged as a new piece of the puzzle linking Epstein-Barr virus (EBV) infections to multiple sclerosis (MS), according to a study. Researchers found that immune T-cells from people with MS can mistake ANO2 for an EBV protein, triggering a cross-reactive response that directly damages myelin-producing cells and worsens…
Science is a risky Business
Tweet We all know that having MS is a risk factor for unemployment, but likewise UK University life has increasingly become a risk factor for the academic. The Times Higher Educational Supplement reports redunancies of about 30,000 staff over the past three years with 13,000 getting the boot or asking to be kicked out just…
Myelin Basic Protein back in the Sights of EBV
Tweet Do we think that the gene products of a baby are going to be the same as an adult? Therefore it would not be surprising if EBV influneces what genes are active because one thing it does is…..change the B cell from having the features and coat of a naive B cell to become…
What I learned in 2025
The post What I learned in 2025 appeared first on Life on a Seesaw. And what I plan to do differently in 2026 and beyond 2025 has been a real year of change for me. Good change and not-so-good change. Some challenges have forced me to start doing things a bit differently. And there have…
Deja vu…a blast from the past…Not all antibodies bad
Tweet Smith C, Greenberg BM, Reynolds J, Mosavi-Hecht R, Semedo-Kuriki P, Benavides S, Zhang W, Wu Y, Adams G, Evers BM, Telesford KM, Yanev PG, Mettlen M, Stowe AM, Kerr D, Monson NL. A Patient-Derived Antibody Ameliorates Disease Severity in a Relapsing Remitting Murine Model of Multiple Sclerosis. Ann Neurol. 2026. doi: 10.1002/ana.78149. Objective: Naturally occurring…
Emotional Release
Happy Saturday, y’all! I hope you are doing well and that you are ready to have a great weekend. Not much new has happened during the week, and I am still trying to deal with life’s challenges as they are thrown at me. The kitty crew is doing great and thriving, which is amazing. The…
EBV and B cells. Here is the causal mechanism?
Tweet Kim H, Schneider M, Raach Y, Karypidis P, Roux J, Perdikaris G, Holdermann S, Kulsvehagen L, Lecourt AC, Narr K, Sankowski R, Diebold M, Bartoszek-Kandler E, Kapfhammer JP, Zimmer G, Pröbstel AK, Prinz M, Kappos L, Sanderson NSR, Derfuss T. Myelin antigen capture in the CNS by B cells expressing EBV latent membrane protein…
Guest Voice: The VIP of my MS support team? A wall to lean on.
Before multiple sclerosis (MS) entered my life, I never gave ordinary objects a second thought. Walls, for example, were just there, holding up pictures, catching the occasional flying shoe thrown by Mom, or marking where furniture should stop. I didn’t greet the walls or thank them. I certainly didn’t depend on them. Like many things…
Vision & Values
By Stacie Prada I created a vision board years ago that included images of women doing yoga poses I couldn’t do. I attended yoga classes weekly, and I loved how it combined calming breathwork with some of the gymnastics, athleticism, … Continue reading → Source: blog.mymsaa.org
Machine learning model can predict PIRA in first years of MS diagnosis
A new machine learning tool can now help predict whether people newly diagnosed with multiple sclerosis (MS) will experience disability worsening that occurs even in the absence of relapses. According to a recent study, these artificial intelligence algorithms can identify the risk of “progression independent of relapse activity,” or PIRA, using simple clinical data typically…