Tweet JC virus is a common virus and in most cases non-immunosuppressed make an immune response to the virus and keep it in check. However if you are immunosuppressed there is a risk that the virus escapes control and PML develops. There has been some benefit if you take the brakes off immune control and…
Extended Interval Dosing…When will it happen?…Do a pregnancy study
Tweet We have made a suggestion that cladribine, alemtuzumab and anti-CD20 depleters work in the same way and this would suggest that if you dose 3 times (i.e. a year) then you may be able to “watch and wait” just like you do with alemtuzumab and cladribine. This study asks what happens when you stop…
Pursuing quieter, more compassionate examples of self-care
Self-care is often framed as something luxurious, such as spa days, vacations, quiet mornings with coffee, and a to-do list that magically completes itself. But self-care looks different for everyone, especially those who are navigating chronic stress, illness, or caregiving. Living with relapsing-remitting multiple sclerosis, I’ve learned that self-care is often quieter for me: reading…
Dissolvable film may deliver more MS medicine than standard tablets
Bionxt Solutions’ experimental sublingual therapy BNT23001 led to about 40% higher blood exposure to cladribine than a conventional oral tablet formulation, such as those used in multiple sclerosis (MS) therapies like Mavenclad, the company reported. The results come from a preclinical study in adult miniature pigs, an animal model often used in drug research. Bionxt…
Easy Overnight Oats
Making overnight oats is simple and doesn’t require any cooking! This basic recipe can be customized to your liking with various add-ins and flavors. Ingredients: one serving, combine the following in a jar or airtight container: Instructions Source: blog.mymsaa.org
Impact from a trip to Portugal
Tweet In about 2016 ProfG asked MD to go to a conference in Lisbon to talk about how antibodies work in MS. He supplied about 80 slides for a 20minute talk. To be honest the conference was for antibody engineers who didn’t really care about MS and so maybe a reason why ProfG asked MD…
Targeting EBV-infected B-cells may help prevent or treat MS: Study
When immune B-cells mistakenly recognize the body’s own nerve tissue, they can shut themselves down to prevent damage, but infection with the Epstein-Barr virus (EBV) can trick B-cells into surviving and becoming activated in the brain instead of being eliminated by normal immune safety mechanisms, according to a study. These self-reactive B cells can then…
Being honest with myself about MS pain isn’t the easiest thing to do
Over the years, I haven’t always followed the same advice I’ve given others. For instance, when I was in the military, I’d tell soldiers preparing for a Veterans Affairs examination that it wasn’t the time to act tough — they should report their pain honestly and accurately. This initial exam sets the stage for future…
Portable MRI shows strong match with standard scans in neurology clinics
Hyperfine’s Swoop system, the first U.S. Food and Drug Administration (FDA)-cleared AI-powered portable MRI system for the brain, showed strong diagnostic agreement with conventional MRI scans and was preferred by patients, according to new study results. Because Swoop can be used in neurology clinics, it may help make brain imaging more accessible and comfortable for…
Are we thinking of EBV the wrong way?
Tweet There are many people who view that EBV is the cause of MS….but I put forward an idea that EBV is at the centre of alot more problems than MS. Remember about 10% of the population develop autoimmunities compared to the 0.1% who develop MS. Could EBV be at the bottom of more than…