The complement system — part of the immune system that helps defend against infections — may play a key role in age-related disease progression in multiple sclerosis (MS), according to findings from a mouse study. In fact, blocking a complement protein called C3 reduced disease…
For the average person, catching a cold is a minor inconvenience—a few days of tissues and cough syrup before bouncing back to work. But for those of us living with multiple sclerosis (MS), the narrative is often drastically different. We … Continue reading → Source:…
The investigational BTK inhibitor fenebrutinib was as effective as the approved therapy Ocrevus (ocrelizumab) at reducing the risk of disability progression in people with primary progressive multiple sclerosis (PPMS), meeting the main goal of a Phase 3 trial. According to fenebrutinib’s developer, Genentech, the therapy is…
Tweet This week I was arguing that PIRA is a terrible concept because a significant element is due to actions outside the CNS…I suggested that most antibody delivered never reach the CNS. To the average of 80Kg volunteers they give 6mg/kg = 480mg (more than…
The month of February may be a shorter month, but it has left a few empty places in my heart. Of course, despite a couple of heartbreaking events that occurred during February, a few great things also happened. It is, as we have always heard, that you cannot have sunshine…
Despite this, I often refer to MS as a lonely illness. With a vast array of associated neurological and non-neurological symptoms spread over four different types of MS, it will be exponentially difficult to find someone who has the exact same symptoms with a similarly…
Tweet This study indicates that rates of brain atrophy are affected by age and that they should be considered. One thinks that would be wise, but one wonders what this would do to the powering of studies (i.e. how big they have to be to…
Tweet This morning I woke up like someone has been punching me in the arm all night and guess it is all related to neck problems but it is part of that dropping to bits as you get older thing. Toss on top of this…
Researchers have developed a mouse model designed to reflect the disability worsening that occurs in the absence of relapses for many people with multiple sclerosis (MS). The model shows key features of this form of disease worsening, known as progression independent of relapse activity (PIRA),…
When living with a chronic illness like multiple sclerosis, building a community for yourself of people who truly get it is incredibly valuable. Having a support network in your life of people who are there for you in easy times … Continue reading → Source:…