Tweet I was at a meeting recently and the manufacturer of a CD20-depleting antibodies had created slides for the speaker that implied that there was no important serious infection risk with their product and I thought this doesn’t really reflect that reported by academics using…
Tweet This study uses a new technique to tell us that the cells in the blood are different to those in the immune organs…it is a bit of a NSS moment for me as we have known this for decades. Cells such as T cells…
To call my medical career a series of random pivots is an understatement. I have multiple sclerosis (MS) to thank for this wandering journey, one with an uncertain destination, but a surprisingly meaningful landing place. Anesthesiology was my first love. I adored tinkering with the…
Specific disease-modifying therapies (DMTs) significantly slow the rate of brain volume loss in adults with multiple sclerosis (MS), a benefit that is directly linked to reduced long-term disability, according to a new review. A network meta-analysis of more than 26,000 patients confirms that therapies most…
Tweet Disability accumulation what drives it? Relapse associated worsening (RAW) or progression independent of relapse activity (PIRA). It says here most of it is due to PIRA but PIRA typically covers all worsening about 30 days after a relapse…One can argue that a significant part…
A signaling molecule called erythropoietin (EPO) plays a key role in allowing the immune system to distinguish the body’s own cells from foreign threats, a study found. The findings could lead to new treatments for diseases like multiple sclerosis (MS), in which the immune system…
Due to my uneasiness with heights, I complained a lot about parachuting throughout my career in the U.S. Army. There’s a small chance, however, that I haven’t been entirely fair. Sure, I was afraid every time, made some less-than-stellar landings, and sustained a few injuries,…
Gadoquatrane, a contrast agent Bayer is developing for MRI scans, showed similar safety and pharmacokinetic (PK) profiles — meaning how a drug moves into, through, and out of the body — in both children and adults. That’s according to data from the Phase 3 QUANTI…
Tweet Everybody wants to get rid of EBV and there are a number of trials testing tenofovir alafenamide fumarate (TAF). This current study however reported that Tenofovir targets JC virus and so inhibits the development of PML. So this is good news. NDG treated PML…
The heat has always been a part of my life in central Texas, whether I liked it or not. Every year, it seemed to linger for longer than most people would have liked. When I was diagnosed with relapsing-remitting multiple sclerosis, I realized the heat…